Mechanisms of action & Classification Adrenergic drugs are medications that stimulate or inhibit adrenergic receptors. Adrenergic receptors mediate the action of noradrenaline, also known as norepinephrine; and adrenaline, also known as epinephrine. Adrenergic neurotransmission is responsible for the body’s sympathetic response - the “fight or flight” state - which dilates pupils, increases heart rate and respiratory rate, diverts blood flow to the muscles, inhibits activities that are not essential in emergency, and releases stored energy. Adrenergic receptors are also active in the central nervous system, in processes such as memory and alertness. There are several types of adrenergic receptors,all of which are G-protein coupled, but they differ in several aspects:- They couple with different G-proteins, leading to different downstream signalings, and hence different cellular responses. - They differ in sensitivity to different drugs. - While several receptors may coexist i...
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